com/. The City of Henderson strives to provide its residents with the highest quality of life in Southern Nevada. Henderson’s purpose is to provide an economically thriving community where residents can live, learn, work and play through innovative and premiere public services and amenities. Henderson occupies the southern rim of the Las Vegas Valley stretching east of Boulder Highway to just east of Interstate 15. It's a commitment to enhancing the quality of life for our beautiful community while contributing through public service. Features include level desert, access to the Colorado River, Lake Mead, and Sloan Canyon National Conservation area, along with Black Mountain and the River and McCullough Mountains. Incorporated in 1953, Henderson is Nevada’s second largest city with more than 359,000 residents. The Henderson, NV is not responsible for the content of external sites. Requests are tracked and routed to the appropriate department for response. From shopping and culture to outdoor recreation and entertainment, Henderson is the safe, easily-accessible, and charming heart of Southern Nevada.